Alert System Skill

Automated monitoring and alerting for drug discovery intelligence.

Quick Start

/alerts --create --target "EGFR inhibitors" --events clinical,fda
/alerts --list
/alerts --check my-alert

What's Included

Alert Type	Description	Sources
Clinical Updates	Trial status changes	ClinicalTrials.gov
Regulatory	FDA/EMA decisions	FDA, EMA
Publications	New papers on target	PubMed
Competitor	Pipeline updates	Press releases
Patent	New patent filings	USPTO, EPO
Conference	Meeting abstracts	ASCO, ESMO

Alert Configuration

name: EGFR Competitive Alerts
description: Monitor EGFR inhibitor landscape

targets:
  - EGFR
  - Exon 19 deletion
  - T790M
  - C797S

competitors:
  - AstraZeneca
  - Johnson & Johnson
  - Roche

events:
  - clinical_trial_updates
  - regulatory_approvals
  - publications
  - patent_filings

filters:
  phase: [2, 3]
  countries: [US, EU, CN, JP]
  minimum_significance: high

notifications:
  email: user@example.com
  frequency: weekly
  format: summary

Output Structure

# Alert Report: EGFR Landscape (Weekly)

## Summary
| Alert Type | New | Total |
|------------|-----|-------|
| Clinical Updates | 3 | 127 |
| Publications | 12 | 456 |
| Regulatory | 1 | 23 |
| Patent Filings | 5 | 89 |

## Clinical Trial Updates

### New Trials
| NCT ID | Sponsor | Phase | Indication | Status |
|--------|---------|-------|------------|--------|
| NCT01234567 | AstraZeneca | 3 | NSCLC | Recruiting |
| NCT01234568 | Johnson & Johnson | 2 | NSCLC | Not recruiting |

### Status Changes
| NCT ID | Previous | Current | Date |
|--------|----------|---------|------|
| NCT07890123 | Recruiting | Active, not recruiting | 2024-12-10 |

## Key Publications

1. **Fourth-generation EGFR inhibitors targeting C797S**
   - Journal: Nature Cancer
   - Date: 2024-12-08
   - Authors: Zhang et al.
   - Impact: Novel scaffold for resistance

2. **Combination therapy: EGFR + MET inhibition**
   - Journal: Lancet Oncology
   - Date: 2024-12-05
   - Authors: Smith et al.
   - Impact: Positive Phase 2 results

## Regulatory Updates

### FDA Actions
| Date | Sponsor | Action | Drug |
|------|---------|--------|------|
| 2024-12-12 | AstraZeneca | Approval | Tagrisso (adjuvant) |

## Patent Filings

### New Patents
| Date | Assignee | Title | Patent No. |
|------|----------|-------|------------|
| 2024-12-10 | Merck | EGFR C797S inhibitors | US2024/XXX |
| 2024-12-08 | Roche | Antibody-drug conjugate | EPXXX |

## Recommendations

**Action Items**:
1. Review new C797S inhibitor paper - assess differentiation
2. Monitor AstraZeneca adjuvant approval impact
3. Investigate Merck's new patent - potential FTO issue

Event Types

Event	Description	Priority
Clinical trial starts	New trial initiated	Medium
Clinical trial completes	Primary endpoint reached	High
Regulatory approval	Drug approval	High
Regulatory rejection	CRL, rejection	High
Key publication	High-impact paper	Medium
Competitor deal	M&A, licensing	High
Patent granted	New patent issued	Medium
Patent expiry	Patent expires	Low

Running Scripts

# Create new alert
python scripts/alert_system.py --create my-alert --target "EGFR"

# Check for updates
python scripts/alert_system.py --check my-alert

# List all alerts
python scripts/alert_system.py --list

# Export alert history
python scripts/alert_system.py --export my-alert --format csv

Requirements

pip install requests schedule

# For persistence
pip install sqlalchemy

Reference

• reference/alert-types.md - Alert type reference
• reference/data-sources.md - Data source configuration
• reference/notifications.md - Notification setup

Best Practices

1. Set specific targets: Narrower = fewer false positives
2. Use appropriate frequency: Daily for high-priority, weekly for others
3. Review regularly: Alerts need human interpretation
4. Adjust filters: Refine based on signal-to-noise
5. Document actions: Track alert-driven decisions

Common Pitfalls

Pitfall	Solution
Too many alerts	Narrow target/event filters
False positives	Add confidence filters
Alert fatigue	Adjust frequency and thresholds
Missing context	Include summary with links
No action tracking	Document response to alerts

Alert Frequency Guidelines

Priority	Check Frequency	Notification
Critical	Hourly	Immediate
High	Daily	Daily digest
Medium	Weekly	Weekly summary
Low	Monthly	Monthly report